HP is planning to axe over 1,100 jobs at the start of 2014 across its Bracknell, Sheffield and Warrington hubs.
The country's largest union Unite has branded the move a "blow to the UK's IT sector".
HP recently announced over 7,000 job cuts across the EMEA region, but had previously not given a regional breakdown.
The company has blamed falling demand and reorganisation for the job losses, according to Unite, which it plans to implement in the first three months of next year.
Unite national officer Ian Tonks said: "For the last five years HP has been addicted to a culture of job cuts in the UK to such an extent that its highly skilled workforce has little faith in the way the company is being managed and will be going forward.
"Unite will be doing everything possible to mitigate these job losses which are a hammer blow to the UK's IT sector and very distressing for employees in the run-up to Christmas."
Some 618 jobs could be lost at HP's Bracknell hub (although these employees work at multiple locations), 438 in Warrington, and 23 in Sheffield.
HP said in a statement that the 'workforce management plan' is part of HP's global multi-year productivity initiative and will support the company's turnaround in EMEA.
"HP remains committed to supporting the employability of its employees through a number of internal initiatives, including re-skilling, redeployment and support to obtain alternative employment as appropriate," a spokesperson told Computerworld UK.