Spamihilator is a reasonably easy-to-use spam filter, available in both installable and portable forms.

Configuration was straightforward. The setup wizard launched, detected our copy of Outlook and configured it to use Spamihilator in just a few seconds (and it'll do the same with Thunderbird, Eudora, Opera and many other email programs).

The program then uses Bayesian filters to calculate the probability of a particular email being spam. You can enhance these results further by training the program, helping it identify spam it's missed. A Link filter scans incoming emails for links to known spam websites, the DCC-Filter uses the scan data from millions of email uses to identify junk mails, and you can improve performance even more by installing some very useful free plugins.

Version 1.6:
    •Improved compatibility with mail accounts from Arcor
    •Improved compatibility with 64-bit operating systems
    •Disabled insecure SSLv2 method. SSLv3 and TLS are still available.
    •Prevent SSLv3 POODLE attack
    •Fixed some minor bugs that could cause Spamihilator to crash in certain cases

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There's plenty of spam-blocking power here, but Spamihilator may filter out some genuine emails, too, and the program is only rarely updated these days. Try it, see how it works for you, but if you have problems then move on right away.